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DOE Human Genome Program
Primer on Molecular Genetics
Date Published: June 1992 U.S. Department of Energy Office of Energy Research Office of Health and Environmental Research Washington, DC 20585
The "Primer on Molecular Genetics" is taken from the June 1992 DOE Human Genome 1991-92 Program Report. The primer is intended to be an introduction to basic principles of molecular genetics pertaining to the genome project.
Human Genome Management Information System Oak Ridge National Laboratory 1060 Commerce Park Oak Ridge, TN 37830 Voice: 423/576-6669 Fax: 423/574-9888 E-mail: bkq@ornl.gov
Contents
Primer on Molecular Genetics
Revised and expanded by Denise Casey (HGMIS) from the primer contributed by Charles Cantor and Sylvia Spengler (Lawrence Berkeley Laboratory) and published in the Human Genome 1989–90 Program Report.
Mapping and Sequencing the Human Genome
Low-Resolution Physical Mapping
Chromosomal map
cDNA map
High-Resolution Physical Mapping
Macrorestriction maps: Top-down mapping
Contig maps: Bottom-up mapping
Current Sequencing Technologies
Sequencing Technologies Under Development
Partial Sequencing to Facilitate Mapping, Gene Identification
End Games: Completing Maps and Sequences; Finding Specific Genes
Informatics: Data Collection and Interpretation
Collecting and Storing Data
Interpreting Data
Mapping Databases
Sequence Databases
Nucleic Acids (DNA and RNA)
Proteins
Impact of the Human Genome Project
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